THUNDER Imager 3D Cell Culture System

The Leica THUNDER Imager is an advanced fluorescence imaging system designed for 3D cell culture applications, including stem cells, spheroids, and organoids. Powered by Leica Computational Clearing technology, it removes out-of-focus blur in real time to produce sharp, high-contrast images of complex 3D specimens. With high sensitivity and low phototoxicity, the THUNDER Imager delivers physiologically relevant data while supporting every stage of the imaging workflow—from experiment setup to image acquisition and data analysis.

Key Features

Real-time Computational Clearing for blur-free 3D imaging
Optimized for stem cells, spheroids, and organoids
High-sensitivity fluorescence imaging with low phototoxicity
Fast, high-quality imaging of thick biological samples
Integrated workflow from acquisition to data analysis
Ideal for cell biology, regenerative medicine, and biomedical research
User-friendly software for efficient experiment management

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Technical Specifications

Specification	Details
Imaging Modes	Widefield (including THUNDER)
Workflow	Navigator
Stand	DMi8
Focus	Motorized, Closed-Loop AFC (Hardware Focus for Fast Focusing & Drift Correction)
Stage	QUANTUM High-Speed Stage (Real-Time Controlled with Synapse), Motorized Scanning Stage, or Fixed Stage
Transmitted Light Contrast & Method	Brightfield (BF), Differential Interference Contrast (DIC), Phase Contrast
External Filter Wheel (EFW)	Optional, Supports up to 8 Dyes (24 ms Switch Time)
Filter Cubes	Single to Quad Configuration
Fluorescence Illumination	EL6000, pE300, pE800 MB, or pE800 Fura
Incubation	Optional Cage & Stage-Top Systems (e.g., Okolab, Tokai Hit)
Detection	Hamamatsu Fusion or Kinetix22 (22 mm Field of View)

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THUNDER Imager 3D Cell Culture System